Piperazine derivatives and their acid addition salts

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 295/14 (2006.01) C07D 213/74 (2006.01) C07D 265/36 (2006.01) C07D 267/14 (2006.01) C07D 279/16 (2006.01) C07D 295/084 (2006.01) C07D 295/108 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1238636

Abstract: A piperazine derivative according to the present invention has the following general formula [I]: Image [I] wherein R1 is -OH, -OR3, -SR3, -SOR3 or -SO2R3 wherein R3 is alkyl group having 1 to 3 carbon atoms; R2 is -SO2NH2, -SO2NHR4, -SO2NR4R5, -COOH, -COOR4, -CONH2, -CONHR4, -CONR4R5, -NHCONH2, -NHCSNH2, -NHCONHR4, -NHCOR4 or -NHSO2R4 wherein R4 and R5 are independently group having 1 to 3 carbon atoms; or R1 and R2 together with carbon atoms to which they are attached form Image Z is -CO- or -CH(OH)-; Ar is pyridyl or substituted or unsubstituted phenyl; and n is an integer of 3 to 5. - 1 -

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