Penetrating topical pharmaceutical compositions containing...

Details Penetrating topical pharmaceutical compositions containing... Penetrating topical pharmaceutical compositions containing...

A - Human Necessities

61

K

167/220

A61K 31/52 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01) A61K 47/18 (2006.01) A61K 47/20 (2006.01) A61K 47/24 (2006.01)

Patent

CA 1200497

PENETRATING TOPICAL PHARMACEUTICAL COMPOSITIONS CONTAINING 9-(2-HYDROXYETHOXYMETHYL) GUANINE ABSTRACT A group of hydrophilic substituted purine antivirals, especially 9-(2-hydroxyethoxymethyl) guanine, can be effectively delivered across skin by incorporating the selected antiviral into a binary, penetration-enhancing vehicle containing (1) a C3-C4 diol, diol ester or diol ether, and (2) a cell-envelope disordering compound. These compositions provide surprising enhancement of delivery for the antivirals when compared to existing vehicles or systems, and provide a method of treating viral infections. They are especially effective as antiherpetics.

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