Assay kit containing 16.alpha. halogen substituted...

Details Assay kit containing 16.alpha. halogen substituted... Assay kit containing 16.alpha. halogen substituted...

G - Physics

01

N

167/40, 167/47

G01N 33/60 (2006.01) A61K 51/04 (2006.01) C07J 1/00 (2006.01) G01N 33/534 (2006.01)

Patent

CA 1178885

ABSTRACT OF THE DISCLOSURE 16.alpha.-Radiohalo-3,17.beta.-dihydroxy steroidal estrogens and their radiolabelled analogs are described. These steroidal estrogens have high estrogen receptor activity and are prepared by halogen exchange with the corresponding 16.beta.-bromo compound. The radiolabelled estrogens of this invention are useful in estrogen receptor assays, radio- immunoassays, in vivo imaging of tissue having estrogen receptor activity, and for therapeutic treatment of tumors having estrogen receptor activity.

370779

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