Sulfur-containing 6-ketoprostaglandins

Details Sulfur-containing 6-ketoprostaglandins Sulfur-containing 6-ketoprostaglandins

C - Chemistry, Metallurgy

07

F

167/205, 260/235

C07F 7/08 (2006.01) C07C 405/00 (2006.01) C07D 309/12 (2006.01)

Patent

CA 1251788

Abstract: Sulfur-containing 6-ketoprostaglandins of the formula I Image I in which D is a bond, alkylene having 1-3 C atoms, cis-alkenylene having 2-5 C atoms or alkinylene having 2-5 C atoms, R1 is H, alkyl having 1-4 C atoms, aryl having 6-12 C atoms or -C6H4NHCOC6H5, R2 is alkyl having 1-7 C atoms, alkyl having 1-7 C atoms which is substituted by halogen, cycloalkyl having 5-6 C atoms, cycloalkyl having 5-6 C atoms which is sub- stituted by alkyl having 1-4 C atoms, phenyl, phenyl which is substituted by F, Cl, Br, alkyl having 1-4 C atoms, OH, OCH3 or CF3, pyridyl, naphthyl, thienyl or, if D is alkylene having 1-3 C atoms, also is alkoxy having 1-4 C atoms, alkylthio having 1-4 C atoms, phenoxy or phenoxy which is substituted by F, Cl, Br, alkyl having 1-4 C atoms, OH, OCH3 or CF3, R3 and R4 each are H, alkyl having 1-7 C atoms, tetra- hydro-2-pyranyl, trialkylsilyl having a total of 3-12 C atoms, aryldialkylsilyl having a total of 8-18 C atoms, alkoxymethyl having 2-5 C atoms, aryloxymethyl having 7-11 C atoms or acyl having 1-10 C atoms, and R5 is H or alkyl having 1-3 C atoms, and ....... indicates that this bond is .alpha., Image indicates that this bond is .beta., and, where R1 is H, their salts, show effects on the circulation, in particular hypotensive effects, as well as effects on the force of myocardial contraction.

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