Sorbinil by optical resolution of precursor 6-fluoro-...

Details Sorbinil by optical resolution of precursor 6-fluoro-... Sorbinil by optical resolution of precursor 6-fluoro-...

C - Chemistry, Metallurgy

07

D

260/305.3, 260/3

C07D 311/68 (2006.01) C07D 311/22 (2006.01) C07D 491/10 (2006.01) C07D 491/107 (2006.01)

Patent

CA 1202034

ABSTRACT OF THE DISCLOSURE Sorbinil of formula (I) is obtained by cyclization of S-6-fluoro-4-ureidochromane-4-carboxylic acid, which is in turn obtained by resolution of racemic 6-fluoro-4-ureido-chroman-4- carboxylic acid of formula (III) via diastereomeric salts with either D-(+)-1-phenethyl)amine or L-(-)-ephedrine, this novel process giving high yields of sorbinil using readily available, relatively inexpensive optically active amines. Image (I) Image (III)

440665

Affiliated with

Also associated with

Rating

Sorbinil by optical resolution of precursor 6-fluoro-... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sorbinil by optical resolution of precursor 6-fluoro-..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sorbinil by optical resolution of precursor 6-fluoro-... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1318828