Dihydropyridyl cyclic imidate esters and their...

Details Dihydropyridyl cyclic imidate esters and their... Dihydropyridyl cyclic imidate esters and their...

C - Chemistry, Metallurgy

07

D

167/215, 167/231

C07D 413/04 (2006.01) C07C 205/56 (2006.01) C07D 209/18 (2006.01) C07D 211/90 (2006.01) C07D 213/55 (2006.01) C07D 263/10 (2006.01) C07D 263/14 (2006.01) C07D 263/28 (2006.01) C07D 265/08 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01)

Patent

CA 1238046

DIHYDROPYRIDYL CYCLIC IMIDATE ESTERS Abstract of the Disclosure A series of 1,4 dihydropyrid-5-yl cyclic imidate esters have been prepared possessing the general formula Image wherein R and R1 are independently selected from H, lower alkyl or alkoxyalkyl groups; R2 is lower alkyl, aryl, or hetaryl, R3 is cyclo- alkyl, aryl or hetaryl, generally with electron-withdrawing substituents; R4 is lower alkyl, alkoxyalkyl, aminoalkyl, haloalkyl, or dialkyl- aminoalkyl; R5 is lower alkyl or aryl; m is 0 or 1; and n is 0, 1, or 2. Compounds of this series demonstrate blockade of calcium ion flux in tissue preparations in vitro and vasodilation in animal testing in vivo. Field of the Invention The heterocyclic carbon compounds of the present invention are cyclic imidate esters linked directly to the 5- position of substituted 1,4-dihydropyridine moieties and these compounds possess bio-affecting properties.

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