Cycloalkyl-substituted-4-aminophenyl derivatives and process...

Details Cycloalkyl-substituted-4-aminophenyl derivatives and process... Cycloalkyl-substituted-4-aminophenyl derivatives and process...

C - Chemistry, Metallurgy

07

C

167/246, 260/577

C07C 217/76 (2006.01) C07C 205/42 (2006.01) C07C 205/56 (2006.01) C07C 225/22 (2006.01) C07C 229/42 (2006.01)

Patent

CA 1285287

A B S T R A C T The invention relates to cycloalkyl substituted 4-aminophenyl derivatives of formula (I) Image (I) wherein R is C1-C4 alkyl: n is an integer of 1 to 5; and either (a) A is ?C=O and B is -O-, -NH- or -CH2-; or (b) A is -CH2- and B is -O-, -NH-, -CH2- or ? C=O; or (c) A is -O- and B is ?C=O or -CH2-; or (d) A is -NH- and B is ?C=O or -CH2- , and their pharmaceutically acceptable salts. The scope of the invention includes also a process for prepa- ring the said compounds of formula (I) and pharmaceutical compositions containing same. The compounds of the invention show aromatase inhibiting acti- vity and can be useful, e.g., in treating hormone-dependent tumors and prostatic hypertrophy or hyporplasia.

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