Liquid-phase preparation of delta-keto carboxylic acid...

C - Chemistry – Metallurgy – 07 – C

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260/488, 260/477

C07C 69/716 (2006.01) C07C 69/738 (2006.01)

Patent

CA 1212382

LIQUID-PHASE PREPARATION OF DELTA-KETO CARBOXYLIC ACID ESTERS UTILIZING LIQUID-PHASE INSOLUBLE CATALYST Abstract A process is disclosed for making a delta-keto carboxylic acid ester by the addition reaction of a ketone and an acrylic acid ester in the presence ¦ of a catalyst provided by a mixture of a primary amine component and a water- promoted catalytic material component. The water-promoted catalytic material component, which is substantially or entirely insoluble in the reaction medium, is selected from the group of materials consisting of an alkali half- salt of phthalic acid, an aluminum hydrosilicate mineral, a silica-alumina molecular-sieve zeolite, a silica-free alumina and a sulfonated perfluorinated resin. The process is particularly suitable for making methyl 4-oxocaproate from the addition reaction of acetone and methyl acrylate.

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