Hexahydro-3,5-dioxo-1h-pyrrolizine-2-carboxylic acid and...

Details Hexahydro-3,5-dioxo-1h-pyrrolizine-2-carboxylic acid and... Hexahydro-3,5-dioxo-1h-pyrrolizine-2-carboxylic acid and...

C - Chemistry, Metallurgy

07

D

167/233, 260/299

C07D 487/04 (2006.01)

Patent

CA 1234121

ABSTRACT OF THE DISCLOSURE Hexahydro-3,5-dioxo-1H-pyrrolizine-2-carboxylic acid, its esters, ammonium, metal, and organic amine salts are useful for the treatment of senility, for enhancing memory, and for reversing electroconvulsive shock induced amnesia in humans. Pharmaceutical compositions including these compounds, and a method of treatment employing these pharmaceutical compositions is disclosed. The novel compounds have the general formula: Image (I) wherein A is H, -CH3, phenyl, C3-6alkyl or -(CH2)1-4phenyl, and when A is H an NH? or pharmaceutically acceptable metal or organic amine salt thereof.

462024

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