Immunosuppressor and method of extraction thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

530/15.06, 530/3

C07K 1/14 (2006.01) A61K 35/14 (2006.01)

Patent

CA 1303295

ABSTRACT OF THE DISCLOSURE Novel L-4 suppressor material is extracted from leuko- cytes and purified by size fractionating the extract to produce a first dialyzate having M.wt. cut-off of approximately 12,000, size fractionating the first dialyzate to produce a second dia- lyzate and a retentate at M.wt. cut-off of approximately 3500, applying the retentate to a reverse phase H PLC column, eluting the column, and collecting the eluant associated with the zone of an acetonitrile -diluent aqueous trifluoroacetic acid gradient wherein the Acn concentration is between approximately 75% and approximately 80%. - 17 -

537857

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