Heterocyclic amidoxime derivatives

Details Heterocyclic amidoxime derivatives Heterocyclic amidoxime derivatives

C - Chemistry, Metallurgy

07

D

260/283, 260/317

C07D 209/44 (2006.01) C07D 209/08 (2006.01) C07D 209/46 (2006.01) C07D 209/48 (2006.01) C07D 215/22 (2006.01) C07D 215/227 (2006.01) C07D 217/22 (2006.01) C07D 217/24 (2006.01) C07D 235/26 (2006.01)

Patent

CA 1185603

ABSTRACT OF THE DISCLOSURE Heterocyclic amidoxime derivatives of the general formula: Image wherein R' represents hydrogen or the methyl radical, and R represents the 1-oxo-1H-isoquinolin-2-yl, 2-oxo-2H-quinolin-1-yl, 2,3-dihydro-1H-indol-1-yl, 1,3- dioxo-1,3-dihydro-2H-isoindol-2-yl, 1H-indol-1-yl, 1-oxo- 1,3-dihydro-2H-isoindol-2-yl, 2-oxo-3,4-dihydro-2H-quinolin- 1-yl, 5-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol- 1-yl, 5-chloro-2-oxo-3-phenyl-2,3-dihydro-1H-benzimidazol- 1-yl, 4-chloro-1-oxo-1H-isoquinolin-2-yl or 3-methyl-2- oxo-2,3-dihydro-1H-benzimidazol-1-yl radical, and - when R' represents the methyl radical - racemates and enantiomers of such compounds, are new compounds useful in therapy, and especially for the treatment of complaints of the central nervous system and for the treatment of depression.

403620

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