Process of producing pharmaceutical composition of...

A - Human Necessities – 61 – K

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A61K 31/425 (2006.01) A61K 9/08 (2006.01) C07D 275/00 (2006.01)

Patent

CA 1184495

ABSTRACT OF THE DISCLOSURE By the addition of L-aspartic acid, the solubility of Famotidine in water can be effectively improved for providing a stable aqueous solution of Famotidine for injection. A lyophilized composition of Famotidine for injection is also prepared by lyophilizing an aqueous solution containing Famotidine together with L-aspartic acid and/or L-glutamic acid. Mannitol may be also added to the aqueous solution. as an excipient.

417637

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