Piperidine derivatives

Details Piperidine derivatives Piperidine derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/279

C07D 211/42 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01)

Patent

CA 1336833

The (3R,S)- or (3R)- form of a compound of the formula:- Image --- (I) or a pharmaceutically acceptable salt thereof, wherein R1 is a group of the formula:- Image , Image or Image where each Y, which may be the same or different, is selected from the substituents hydrogen, halo and C1-C4 alkyl; X is -(CH2)2-, -CH=CH-, -CH2-S-, -CH2-O-, -S- or -O-; and R is a group of the formula:- Image , Image , Image or Image , wherein R2, R3, R4 and R5 are certain specified substituents. The compounds are useful in the treatment of diseases associated with altered motility and/or tone of smooth muscle.

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