C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/14, 167/197
C07J 71/00 (2006.01) C07J 1/00 (2006.01) C07J 5/00 (2006.01) C07J 13/00 (2006.01) C07J 21/00 (2006.01) C07J 53/00 (2006.01)
Patent
CA 1239388
Epoxy steroids Abstract 7.alpha.-acylthio-9.alpha.,11.alpha.-epoxy-20-spirox-4-ene-3,21- diones of the formula I Image (I), in which R represents lower alkanoyl and -A-A- represents an ethylene or cyclopropylene group, have a high aldosterone-antagonistic activity without significant sexually-specific side-effects and can be used as potassium-protecting diuretics in the treatment of various forms of hyperaldosteronism. The compounds can be obtained by conventional processes of steroid chemistry.
484418
Fetherstonhaugh & Co.
Novartis Ag
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