Epoxy steroids

C - Chemistry – Metallurgy – 07 – J

Patent

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C07J 71/00 (2006.01) C07J 1/00 (2006.01) C07J 5/00 (2006.01) C07J 13/00 (2006.01) C07J 21/00 (2006.01) C07J 53/00 (2006.01)

Patent

CA 1239388

Epoxy steroids Abstract 7.alpha.-acylthio-9.alpha.,11.alpha.-epoxy-20-spirox-4-ene-3,21- diones of the formula I Image (I), in which R represents lower alkanoyl and -A-A- represents an ethylene or cyclopropylene group, have a high aldosterone-antagonistic activity without significant sexually-specific side-effects and can be used as potassium-protecting diuretics in the treatment of various forms of hyperaldosteronism. The compounds can be obtained by conventional processes of steroid chemistry.

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