C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/241.15, 260/
C07D 403/12 (2006.01) C07C 59/64 (2006.01) C07D 209/16 (2006.01) C07D 209/18 (2006.01) C07D 223/16 (2006.01) C07D 491/056 (2006.01)
Patent
CA 1225089
Abstract This invention relates to compounds of general formula I Image (I) [wherein A represents a -CH2-CH2-, -CH=CH-, -?H-CO- or -?H2-CO- group and B represents a methylene, carbonyl or thiocarbonyl group, or A represents a -CO-CO- or Image group and B represents a methylene group; E represents a straight-chained alkylene group containing 2 to 4 carbon atoms optionally substituted by an alkyl group containing 1 to 3 carbon atoms, or represents a 2-hydroxy-n-propylene, 2-hydroxy-n-butylene or 3-hydroxy-n-butylene group; G represents a straight-chained alkylene group containing 1 to 5 carbon atoms optionally substituted by an alkyl group containing 1 to 3 carbon atoms; R1 represents a hydrogen, chlorine or bromine atom or a trifluoromethyl, nitro, amino, alkylamino, dialkylamino, alkyl, hydroxy, alkoxy or phenylalkoxy group (in which each alkyl moiety may contain 1 to 3 carbon atoms) and R2 represents a hydrogen, - 61 - chlorine or bromine atom or a hydroxy, alkoxy, phenylalkoxy or alkyl group (in which each alkyl moiety may contain 1 to 3 carbon atoms); or R1 and R2 together represent an alkylenedioxy group containing 1 or 2 carbon atoms; R3 represents a hydrogen, chlorine or bromine atom or an alkyl group containing 1 to 4 carbon atoms; R4 represents a hydrogen atom or an alkyl or phenylalkyl group (in which each alkyl moiety may contain 1 to 3 carbon atoms); R5 represents a hydrogen, fluorine, chlorine or bromine atom or an alkyl, hydroxy, alkoxy or phenylalkoxy group (in which each alkyl moiety may contain 1 to 3 carbon atoms); R6 represents a hydrogen atom or an alkoxy group containing 1 to 3 carbon atoms; and R7 represents a hydrogen atom, an alkenyl group containing 3 to 5 carbon atoms or an alkyl or phenylalkyl group (in which each alkyl moiety may contain 1 to 3 carbon atoms)] and acid addition salts thereof which have interesting pharmacological properties, particularly a heart rate-lowering activity. The new compounds may be obtained using methods known per se.
469010
Austel Volkhard
Hauel Norbert
Heider Joachim
Kobinger Walter
Lillie Christian
Fetherstonhaugh & Co.
Thomae (dr. Karl) Gesellschaft Mit Beschrankter Haftung
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