Recombinant lymphotoxin

Details Recombinant lymphotoxin Recombinant lymphotoxin

C - Chemistry, Metallurgy

12

N

530/13, 167/37,

C12N 15/28 (2006.01) A61K 38/19 (2006.01) C07K 1/22 (2006.01) C07K 14/525 (2006.01) C07K 16/24 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340641

Biologically active lymphotoxin polypeptides are synthesized in recombinant cell culture. Novel nucleic acid and vectors incorporating same are provided. The compositions and processes herein enable the economical preparation of compositions containing uniform lymphotoxin polypeptides and variant lymphotoxins having amino acid sequences that differ from those found in nature. The lymphotoxins are purified to a specific activity of 2-10x10 7 units/mg of protein by purification using a novel immobilized, lymphotoxin-neutralizing monoclonal antibody.

482995

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