Process for the carbonylation of arylalkyl halides

Details Process for the carbonylation of arylalkyl halides Process for the carbonylation of arylalkyl halides

C - Chemistry, Metallurgy

07

C

260/507.1, 260/2

C07C 57/30 (2006.01) C07C 51/10 (2006.01) C07C 59/66 (2006.01) C07C 59/84 (2006.01)

Patent

CA 1338592

A method is provided for the preparation of alpha-aryl- propionic acids such as ibuprofen by carbonylating the corresponding 1-arylethyl halide in an acidic aqueous medium containing a palladium catalyst. In the preparation of ibuprofen, 1-(4'-isobutylphenyl)ethyl halide is reacted with carbon monoxide in an acidic aqueous medium containing a palladium catalyst.

596739

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