Covalently bonded active agents with carbonium ion base groups

Details Covalently bonded active agents with carbonium ion base groups Covalently bonded active agents with carbonium ion base groups

C - Chemistry, Metallurgy

07

D

167/179, 260/23,

C07D 317/34 (2006.01) A61K 31/58 (2006.01) A61K 47/48 (2006.01) C07D 319/06 (2006.01) C07J 17/00 (2006.01)

Patent

CA 1321577

ABSTRACT The invention relates to a unique set of compositions of matter characterized by including defined active agents covalently bonded to carbonium ion base groups, as well as the method of creating the compositions. The covalently bonded compositions include base groups in the nature of ketene acetals and vinyl ethers and the thio equivalents thereof. The available active agents include alcohols, phenols, carboxylic acids, thiols, amines, amides, urethanes, phosphate esters, sulfonic acids and oximes. The compositions may either be in capped form or leashed to a polymeric backbone. The compositions are ordinarily formed by self actuating reactions when the appropriate base groups and active agents are juxtaposed under proper environmental conditions. The primary uses of the compositions are in controlled release applications such as drugs, topical insecticides and the like or in any application where predictable hydrolytic release of the active agent is desirable.

574727

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