Method for controlling emesis caused by chemotherapeutic...

Details Method for controlling emesis caused by chemotherapeutic... Method for controlling emesis caused by chemotherapeutic...

A - Human Necessities

61

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167/208, 260/278

A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/445 (2006.01) A61K 31/675 (2006.01) A61K 33/24 (2006.01) C07D 207/09 (2006.01)

Patent

CA 1315793

ADR 090 P2 Abstract of the Disclosure A method for alleviating emesis caused by chemotherapy which comprises administering an antiemetic agent or a pharmaceutically acceptable salt thereof to a patient in conjunction with the administration of a chemotherapeutic agent, said antiemetic agent being represented by the formula (I) Image wherein Z represents a substituent such as a lower alkyl group, a methoxyethoxymethyl group, or a benzoylmethyl group; or Z in conjunction with the adjacent position represents the atoms necessary to complete a 5 to 7 membered saturated or unsaturated oxygen-containing ring; R represents a hydrogen atom, a halogen atom, a lower alkyl group, a cycloalkyl group, a lower alkoxy group, an amino group, a lower alkyl-substituted amino group, an acylamido group, a sulfamoyl group, a sulfonamido group or a nitro group; n is an integer of 1 to 3; W is a straight chain or branched chain alkylene group of 1 to 4 carbon atoms; and X represents the atoms necessary to complete a 5 or 6 membered ring; said antiemetic agent being administered in an amount and in a manner which alleviates emesis associated with said chemotherapeutic agent; and certain new antiemetic agents useful in said method.

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