Process for converting preproinsulin analogs into insulin

Details Process for converting preproinsulin analogs into insulin Process for converting preproinsulin analogs into insulin

C - Chemistry, Metallurgy

12

P

195/128.2

C12P 21/02 (2006.01) C07K 14/62 (2006.01)

Patent

CA 1195273

Abstract of the disclosure: The invention relates to a process for the prepara- tion of insulins from analogs of preproinsulins, which comprises reacting preproinsulin analogs, at a pH below the isoelectric point of the insulins in the presence of trypsin or a trypsin-like endopeptidase, wit an ester of natu- ral amino acids or their derivatives and then cleaving off the ester group and other protective groups which may op- tionally be present.

423391

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