G - Physics – 01 – N
Patent
G - Physics
01
N
167/44
G01N 33/80 (2006.01) G01N 33/555 (2006.01)
Patent
CA 1179260
RAN 4093/56 Abstract There is described a method for the determination of antigens or antibodies in a fluid by incubation of particles, which have antigens on the surface, and antibodies, whereby either the antigens or the antibodies are of known specificity. The characteristic feature for the novel method is that the antigen/antibody complex is introduced into a container having a conical-shaped or keel-shaped bottom recess, whereby at least the recess of the container is coated with an immunoglobulin-binding component which is directed against the antibodies. After centrifugation the amount of the sediment is determined, which gives the answer whether the antigen or antibody to be determined is present or not. The antigen/antibody complex is freed from unbound immunoglobulins before and/or after the introduction into the container. As antigens which are to be determined there come especially into consideration blood group antigens. As the immunoglobulin-binding component there come into consideration anti-immunoglobulins or protein A.
393925
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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