Method and agents for arresting fulminating infection

A - Human Necessities – 61 – L

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167/103, 167/114

A61L 15/46 (2006.01) A61K 31/74 (2006.01) A61K 33/00 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 38/40 (2006.01)

Patent

CA 1197779

ABSTRACT OF THE DISCLOSURE Agents for the arrest of infections resulting from organism growth in contact with an iron-containing body fluid. The agents are capable of immobilizing the body fluid so that the iron it contains is nutritionally unavailable for the organism. In the instance where the body fluid is blood, the agent may be administered in amounts effective to bind all of the available red blood cells or hemoglobin, to pre- vent breakdown of either and consequent release of iron to the organism. The agents preferably include materials capable of binding red blood cells and iron, such as haptoglobin, colloidal silica, anion exchange resins and mixtures thereof. Preferably, colloidal silica is used either alone or in a composite with a polyolefin elastomer such as polyisobutylene. The agents may be coated on carriers or substrates, such as gauze pads, tampons and the like, and may be thus utilized topically, as well as intraperitoneally.

402167

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