Carboxycyclopropylglycine and process for producing the same

Details Carboxycyclopropylglycine and process for producing the same Carboxycyclopropylglycine and process for producing the same

C - Chemistry, Metallurgy

07

C

260/518

C07C 229/46 (2006.01) C07C 227/32 (2006.01)

Patent

CA 1305177

CARBOXYCYCLOPROPYLGLYCINE AND PROCESS FOR PRODUCING THE SAME ABSTRACT OF THE DISCLOSURE: A novel compound (2S,3R,4S)-carboxycyclopropylglycine represented by the formula (1): Image (1) has proved to be the most potent agonist binding specifi- cally to N-methyl-D-aspartate (NMDA) which is one of the receptor types in the central nervous system of mammalian animals. This compound may have therapeutic value in epilepsy, neuronal disorders such as Hutchinson's disease and Parkinsonism, as well as various acute and chronic neurodegenerative disorders. Also disclosed is a process for producing this compound, as well as a process for individually synthesizing four carboxycyclopropylglycine stereoisomers including those of the following formulas (1a, 1b, 1c): Image Image Image (1a) (1b) (1c) and the formula (1).

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