Improving antibody expression using vectors containing...

Details Improving antibody expression using vectors containing... Improving antibody expression using vectors containing...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C07K 16/00 (2006.01) C12N 15/00 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2611465

The present invention relates to the improved production of a therapeutic antibody comprising the use of insulator elements flanking the immunoglobulin sequence(s). Cell survival is also improved with the increase in the number of insulator elements.

La présente invention concerne un procédé pour produire de façon améliorée un anticorps thérapeutique. Ce procédé consiste à utiliser des éléments d'isolation qui flanquent la ou les séquences d'immunoglobuline. Il est également possible d'améliorer la survie des cellules en augmentant le nombre d'éléments d'isolation.

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