Treatment of neuropathic pain with zinc finger proteins

Details Treatment of neuropathic pain with zinc finger proteins Treatment of neuropathic pain with zinc finger proteins

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) A61K 48/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2562193

A variety of zinc finger proteins (ZFPs) and methods utilizing such proteins are provided for use in treating neuropathic pain. ZFPs that bind to a target site in genes that are aberrantly expressed in subjects having neuropathic pain are described. In addition, ZFPs that bind to a target site in genes expressed at normal levels in subjects experiencing neuropathic pain, modulation of whose expression results in decreased pain perception, are also provided. For example, genes that are over-expressed in the dorsal root ganglia (DRG) of pain patients (e.g.,VR1, TRKA and/or Nav1.8) can be repressed, whereas genes that are under-expressed in the same populations can be activated.

L'invention concerne une variété de protéines à doigts de zinc (ZFP) et des méthodes mettant en application ces protéines afin de traiter la douleur neuropathique. Elle concerne des protéines à doigts de zinc se liant à un site ciblé dans des gènes exprimés de façon aberrante chez des individus souffrant de douleurs neuropathiques. Elle concerne, de plus, des protéines ZFP se liant à un site ciblé de gènes exprimés à des niveaux normaux chez des individus souffrant de douleurs neuropathiques, dont la modulation de l'expression permet d'atténuer la perception de la douleur. Par exemple, les gènes surexprimés dans les ganglions de l'épine dorsale (DRG) de patients (par exemple, VR1, TRKA et/ou Nav1.8) peuvent être réprimés, tandis que des gènes sous-exprimés dans les mêmes populations peuvent être activés.

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