Octahydropyrano[3,4-c]pyrrole tachykinin receptor antagonists

Details Octahydropyrano[3,4-c]pyrrole tachykinin receptor antagonists Octahydropyrano[3,4-c]pyrrole tachykinin receptor antagonists

A - Human Necessities

61

K

A61K 31/401 (2006.01) C07D 491/052 (2006.01)

Patent

CA 2590039

The present invention is directed to certain hydropyranopyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depresssion, and anxiety.

La présente invention se rapporte à certains composés d'hydropyranopyrrolidine, utiles comme antagonistes du récepteur de la neurokinine-1 (NK-1) et comme inhibiteurs de la tachykinine, en particulier de la substance P. Cette invention concerne également des formulations pharmaceutiques comprenant ces composés comme ingrédients actifs ainsi que l'utilisation de ces composés et de leurs formulations dans le traitement de certains troubles, parmi lesquels figurent le vomissement, l'incontinence urinaire, la dépression et l'anxiété.

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