Fused ring thiophene dyes for imaging and therapy

Details Fused ring thiophene dyes for imaging and therapy Fused ring thiophene dyes for imaging and therapy

C - Chemistry, Metallurgy

07

D

C07D 495/14 (2006.01) A61K 31/381 (2006.01) A61K 41/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2737912

The invention provides optical agents, including compositions, preparations and formulations, and methods of using and making optical agents. Optical agents of the present invention include oligomer dyes, and derivatives thereof, having a fused ring backbone structure having an oligothiophene core. In some embodiments, oligomer dyes of the present invention are fused ring thiophene dyes having an oligothiophene core comprising a plurality of fused thiophene, thiophene-oxide, and/or thiophene-dioxide rings, optionally functionalized to provide useful optical, biological, pharmacokinetic and/or physical properties. The compounds are dithieno [3,2-b;2',3' -d] thiophene derivatives.

La présente invention concerne des agents optiques, comprenant des compositions, des préparations et des formulations, et des procédés dutilisation et de fabrication des agents optiques. Les agents optiques de la présente invention comprennent des colorants oligomères, et des dérivés de ceux-ci, ayant une structure squelette à cycles fusionnés comprenant un noyau oligothiophène. Dans certains modes de réalisation, les colorants oligomères de la présente invention sont des colorants thiophènes à cycles fusionnés ayant un noyau oligothiophène comprenant une pluralité de cycles thiophène, oxyde de thiophène, et/ou dioxyde de thiophène fusionnés, éventuellement fonctionnalisés afin de fournir des propriétés optiques, biologiques, pharmacocinétiques et/ou physiques utiles. Les composés sont des dérivés dithiéno[3,2-b;2',3'-d]thiophènes.

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