A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/05 (2006.01) A61K 31/40 (2006.01) A61K 31/426 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01)
Patent
CA 2689012
The present invention discloses a method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression, insomnia, schizophrenia, epilepsy, spasm and chronic pain. Administration of a suitable DP IV inhibitor leads as a causal consequence to a reduced degradation of the neuropeptide Y (NPY) in the brain of mammals. Such treatment will result in a reduction or delay in the decrease of the concentration of functionally active neuronal NPY (1- 36). As a consequence of the resulting enhanced stability of the endogenous NPY (1-36), NPY activity is prolonged thereby resulting among other things in functionally active NPY Y1 receptor activity thereby facilitating antidepressive, anxiolytic, analgesic, antihypertension and other neurological effects.
Demuth Hans-Ulrich
Hoffmann Matthias
Kask Ants
Kruber Susanne
Nguyen Huu Phuc
Macrae & Co.
Probiodrug Ag
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