Synovial cell protein

Details Synovial cell protein Synovial cell protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/564 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2431478

A novel protein synoviolin and a gene encoding the same are disclosed. This protein is expressed specifically in the synovial membrane tissue and associated with an autoantibody which recognizes this protein in patients with rheumatoid arthritis (RA). This protein or its antibody is expected as being useful as an RA-specific diagnostic marker. Moreover, it is expected that an RA remedy could be screened by using the above gene or protein. A transgenic animal of the synoviolin gene is also provided. This transgenic animal is usable as an RA model animal in developing a remedy for RA.

La présente invention concerne une synovioline protéinique et un gène codant pour celle-ci. Cette protéine est spécifiquement exprimée dans le tissu de la membrane synoviale et elle est associée à un autoanticorps qui reconnaît cette protéine chez des patients atteints d'arthrite rhumatoïde. On pense que cette protéine ou son anticorps convient comme marqueur de diagnostic spécifique de l'arthrite rhumatoïde. Par ailleurs, on pense pouvoir rechercher un médicament pour cette maladie au moyen de ce gène ou de cette protéine. Cette invention concerne aussi un animal transgénique de ce gène. On peut utiliser cet animal transgénique comme animal modèle de l'arthrite rhumatoïde dans l'élaboration d'un médicament permettant de lutter contre cette maladie.

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