Tablets quickly disintegrated in oral cavity

Details Tablets quickly disintegrated in oral cavity Tablets quickly disintegrated in oral cavity

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/00 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/16 (2006.01) A61K 47/26 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01) A61K 47/42 (2006.01) A61P 15/10 (2006.01) A61P 43/00 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2437754

The present invention is directed to intraorally rapidly disintegrating tablets which, when ingested, disintegrate in the oral cavity rapidly without presenting an unpleasant taste, can be quickly absorbed in the digestive tract and express efficacy. The intraorally rapidly disintegrating tablets contain a drug being hardly water-soluble under neutral or alkaline conditions and being highly water-soluble under acidic conditions yet presenting unpleasant taste, which tablets can be prepared by combining the medicinal substance with a water-soluble acidic substance, coating either or both of the substances with a water-soluble coating agent being insoluble in alcoholic solvent, further adding a water--soluble binding agent being soluble in alcoholic solvent and a water-soluble saccharide, subjecting the resultant mixture to compression, and treating the products with an alcoholic solvent.

L'invention concerne des comprimés se dissolvant rapidement dans la cavité buccale et n'entraînant pas de sensation de mauvais goût. Ces comprimés sont rapidement absorbés dans le système digestif, d'où l'action rapide d'une substance active associée. Lesdits comprimés contiennent un médicament faiblement hydrosoluble dans des conditions neutres ou alcalines mais hautement hydrosoluble dans des conditions acides, ce médicament entraînant généralement une sensation de mauvais de goût. Ils peuvent être produits par mélange du médicament avec une substance acide hydrosoluble, par enrobage d'un ou de plusieurs de ces éléments dans un film insoluble dans les solvants à base d'alcool, par ajout d'un ou de plusieurs saccharides hydrosolubles et d'un liant hydrosoluble pouvant se dissoudre dans les solvants à base d'alcool, par moulage de ce mélange à une faible pression, puis par traitement au moyen d'un solvant à base d'alcool.

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