Release of antibiotic from injectable, biodegradable...

Details Release of antibiotic from injectable, biodegradable... Release of antibiotic from injectable, biodegradable...

C - Chemistry, Metallurgy

08

L

C08L 75/06 (2006.01) A61K 31/7036 (2006.01) A61K 47/34 (2006.01) A61P 17/02 (2006.01) C08K 5/17 (2006.01)

Patent

CA 2698707

A biodegradable polyurethane scaffold, comprising at least one polyisocyante, polyisocyanate prepolymer, or both, at least one polyester polyol, at least one catalyst, wherein the density of said scaffold is from about 50 to about 250 kg m-3 and the porosity of the scaffold is greater than about 70 (vol %) and at least 50% of the pores are interconnected with another pore, and wherein the scaffold incorporates at least one biologically active component in powder form.

La présente invention concerne un tuteur en polyuréthane biodégradable, comprenant au moins un élément choisi parmi un polyisocyanate et un prépolymère de polyisocyanate ou les deux, au moins un polyol de polyester, au moins un catalyseur, la densité dudit tuteur étant comprise entre environ 50 et environ 250 kg/m3, sa porosité étant supérieure à environ 70 (% en volume), au moins 50 % des pores étant interconnectés avec un autre pore et le tuteur intégrant au moins un composant biologiquement actif se présentant sous la forme d'une poudre.

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