A vaccinia virus protein a46 peptide and use thereof

Details A vaccinia virus protein a46 peptide and use thereof A vaccinia virus protein a46 peptide and use thereof

A - Human Necessities

61

K

A61K 39/285 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/005 (2006.01) C07K 14/07 (2006.01)

Patent

CA 2744120

A peptide for inhibiting Toll-like receptor 4 (TLR4) signalling comprising the amino acid sequence of SEQ ID NO. 4, SEQ ID NO 55, SEQ ID NO 68, SEQ ID NO. 69, SEQ ID NO 70, SEQ ID NO 71, SEQ ID NO 72, SEQ ID NO 79, SEQ ID NO 82, SEQ ID NO 85, SEQ ID NO 88, SEQ ID NO 91, SEQ ID NO 94, SEQ ID NO 97, SEQ ID NO 100, SEQ ID NO 103, SEQ ID NO 106, SEQ ID NO 109, SEQ ID NO 112, or SEQ ID NO 115. The peptide may comprise a delivery sequence such as a cationic peptide.

La présente invention concerne un peptide pour inhiber la signalisation du récepteur Toll-like 4 (TLR4) comprenant la séquence dacides aminés de SEQ ID NO 4, SEQ ID NO 55, SEQ ID NO 68, SEQ ID NO 69, SEQ ID NO 70, SEQ ID NO 71, SEQ ID NO 72, SEQ ID NO 79, SEQ ID NO 82, SEQ ID NO 85, SEQ ID NO 88, SEQ ID NO 91, SEQ ID NO 94, SEQ ID NO 97, SEQ ID NO 100, SEQ ID NO 103, SEQ ID NO 106, SEQ ID NO 109, SEQ ID NO 112, ou SEQ ID NO 115. Le peptide peut comprendre une séquence d'administration telle quun peptide cationique.

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