Vitamin d and its analogs in the treatment of tumors and...

Details Vitamin d and its analogs in the treatment of tumors and... Vitamin d and its analogs in the treatment of tumors and...

A - Human Necessities

61

K

A61K 31/59 (2006.01)

Patent

CA 2326117

Treatment of hyperproliferative disorders (including tumors and psoriasis) by pulse administration of a drug (such as Vitamin D or an analog) that increases blood or tissue levels of Vitamin D. The drug is administered at a sufficient dose to have an anti-proliferative effect, but the pulsed administration of the drug avoids the development of severe symptomatic or life-threatening hypercalcemia. In particular embodiments, avoidance of hypercalcemia (as measured by serum levels of calcium above normal range) is avoided altogether. In a particular example, the drug is calcitriol administered at an oral dose of about 0.5 mcg/kg once a week.

L'invention concerne le traitement de troubles d'hyperprolifération (notamment de tumeurs et de psoriasis) par l'administration répétée d'un médicament (tel que la vitamine D ou un analogue de celle-ci) qui accroît les taux de vitamine D dans le sang ou dans les tissus. Le médicament est administré en dose suffisante pour produire un effet d'antiprolifération, sans que l'administration répétée du médicament ne provoque le développement d'une hypercalcémie symptomatique grave ou mettant en danger la vie du sujet. Dans des modes de réalisation particuliers, les risques d'hypercalcémie (mesurée par des taux de calcium sérique supérieurs à la normale) sont entièrement écartés. Dans un exemple particulier, le médicament est du calcitriol administré oralement selon une dose d'environ 0,5 mcg/kg, une fois par semaine.

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