Enhanced brain function by gaba-ergic stimulation

A - Human Necessities – 61 – K

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Details

A61K 31/52 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/53 (2006.01)

Patent

CA 2413405

Methods are disclosed for improving age-related decreases in cortical function by increasing the activity of inhibitory pathways, such as GABA-ergic pathways, in the central nervous system. In particular examples, subjects with age-related decreases in cortical function are treated by administering therapeutically effective amounts of a GABA-ergic agonist. The disclosed methods also enable screening for drugs that inhibit an age-related decline in cortical function, for example by exposing a subject to a test agent, and measuring an increase in GABA-ergic cortical inhibitory activity.

Cette invention concerne des méthodes permettant de ralentir le déclin de la fonction corticale grâce à une augmentation de l'activité des trajets inhibiteurs, tels que les trajets liés à la fonction GABA-ergique, dans le système nerveux central. Dans certains exemples particuliers, des sujets atteints d'une baisse de la fonction corticale liée à l'âge sont traités au moyen de doses thérapeutiquement efficaces d'un agoniste GABA-ergique. Les méthodes selon l'invention permettent également de cribler des médicaments qui inhibent le déclin lié à l'âge de la fonction corticale, par exemple en exposant un sujet à un agent d'essai et en mesurant l'accroissement de l'activité inhibitrice corticale gaba-ergique.

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