Site-specific modification of the candida tropicalis genome

Details Site-specific modification of the candida tropicalis genome Site-specific modification of the candida tropicalis genome

C - Chemistry, Metallurgy

12

P

C12P 7/44 (2006.01) C12N 1/19 (2006.01) C12N 15/00 (2006.01) C12N 15/01 (2006.01) C12N 15/11 (2006.01) C12N 15/81 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2072977

2072977 9106660 PCTABS00005 The POX genes of C. tropicalis are disrupted resulting in the complete blockage of the beta-oxidation pathway in the strain. Fermentation of C. tropicalis cells having disrupted genes on alkane, fatty acid and fatty acid ester substrates produces substantially pure dicarboxylic acids in substantially quantitative yield.

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