Stat3 inhibitors

Details Stat3 inhibitors Stat3 inhibitors

A - Human Necessities

61

K

A61K 31/513 (2006.01) A61K 31/192 (2006.01) A61K 31/195 (2006.01) A61K 31/357 (2006.01) A61K 31/37 (2006.01) A61K 31/427 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2726987

Small molecule inhibitors of Stat3 and their derivatives are disclosed Also described are methods to inhibit cell growth by use of Stat3 inhibitors, and the use of Stat3 inhibitors for the prevention and/or treatment of cancer Further, inhibitors of Stat3 that also do not inhibit Statl are described as well as their derivatives Methods of screening additional compounds for Stat3 inhibition activity and/or non-inhibition of Statl activity are also described herem

L'invention porte sur des inhibiteurs à petites molécules de Stat3 et sur leurs dérivés. L'invention porte également sur des procédés pour inhiber la croissance cellulaire à l'aide d'inhibiteurs de Stat3, et sur l'utilisation d'inhibiteurs de Stat3 pour la prévention et/ou le traitement du cancer. De plus, l'invention porte également sur des inhibiteurs de Stat3 qui n'inhibent pas Stat1 ainsi que sur leurs dérivés. L'invention porte également sur des procédés de criblage de composés supplémentaires pour l'activité d'inhibition de Stat3 et/ou la non inhibition de l'activité de Stat1.

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