Compositions and methods for treating opiate intolerance

Details Compositions and methods for treating opiate intolerance Compositions and methods for treating opiate intolerance

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 31/166 (2006.01) A61K 31/415 (2006.01) A61K 31/4178 (2006.01) A61K 31/439 (2006.01) A61K 31/44 (2006.01) A61K 31/4468 (2006.01) A61K 45/06 (2006.01) A61P 25/36 (2006.01)

Patent

CA 2380524

Provided are compositions comprising an opiate analgesic and an active compound containing the R isomer of N-methylnalorphine in a pharmaceutically acceptable carrier. Also provided are methods of treating opiate intolerance by administration of an active compound containing R N-methylnalorphine or a pharmaceutically acceptable salt thereof. The active compound may be administered either acutely or chronically to subjects receiving opiate treatment. Further provided are methods of inducing analgesia by administering to a subject an opiate analgesic concurrently with an active compound containing R N-methylnalorphine or a pharmaceutically acceptable salt thereof.

La présente invention concerne des compositions comprenant un analgésique opiacé et un composé actif contenant l'isomère R de la N-méthylnalorphine dans un support acceptable d'un point de vue pharmaceutique. Cette invention concerne également des procédés permettant de traiter l'intolérance aux opiacés, par administration d'un composé actif contenant de la N-méthylnalorphine R ou un sel, acceptable d'un point de vue pharmaceutique, de cette dernière. Ledit composé actif peut être administré soit de façon aiguë, soit de façon chronique, à des sujets recevant un traitement opiacé. Cette invention concerne également des procédés permettant d'induire une analgésie, par administration à un sujet d'un analgésique opiacé et, simultanément, d'un composé actif contenant de la N-méthylnalorphine R ou un sel, acceptable d'un point de vue pharmaceutique, de cette dernière.

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