Substituted taraxastanes useful for treating viral infections

Details Substituted taraxastanes useful for treating viral infections Substituted taraxastanes useful for treating viral infections

A - Human Necessities

61

K

A61K 31/56 (2006.01) A61P 31/18 (2006.01) C07J 63/00 (2006.01)

Patent

CA 2643028

Substituted taraxastanes useful for treating viral infections, are provided herein. Thus, in a first aspect, the invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, wherein the variables Ri, R2, and X are defined herein. The compounds described herein are thought to act by inhibiting retroviral maturation, including maturation of encapsulated retroviruses viruses, such as the HIV viruses, HIV-I and HIV-2. Pharmaceutical compositions comprising such compounds of Formula I are included herein. Methods of using such compounds to treat human patients infected with an HIV virus and reducing the mortality of AIDS are also provided herein.

L'invention concerne des taraxastanes substitués utiles pour traiter des infections virales. Ainsi, dans un premier aspect, l'invention concerne des composés de formule I et leurs sels pharmaceutiquement acceptables, formule dont les variables R1, R2 et X sont définies ici. On pense que les composés de l'invention agissent en inhibant la maturation rétrovirale, y compris la maturation de rétrovirus encapsulés tels que les virus VIH-1 et VIH-2. L'invention concerne également des compositions pharmaceutiques contenant les composés de formule I, ainsi que des procédés d'utilisation de ces composés pour traiter des patients humains infectés par un virus VIH et pour réduire la mortalité liée au sida.

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