Role of human kis (hkis) as an inhibitory kinase of the...

Details Role of human kis (hkis) as an inhibitory kinase of the... Role of human kis (hkis) as an inhibitory kinase of the...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61L 27/34 (2006.01) C07K 14/47 (2006.01) C12N 9/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2343099

Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.

L'invention concerne une nouvelle composition et des procédés pour modifier la prolifération d'une cellule, et notamment des polypeptides de hKIS de type sauvage ou mutants ainsi que des inhibiteurs de kinase dépendante des cyclines, qui contiennent des mutations empêchant leur inhibition par des kinases de sérine / de thréonine.

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