A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) A61K 9/70 (2006.01) A61K 31/485 (2006.01) A61K 47/14 (2006.01)
Patent
CA 2147918
A percutaneous absorption preparation which is excellent in the skin penetration of a non-narcotic analgesic buprenorphine and can sustain a high blood level in a stable state over a long period of time is provided. The percutaneous absorption preparation for administrating buprenorphine hydrochloride and/or buprenorphine, which comprises a support having on one surface thereof a plaster layer containing a pressure-sensitive adhesive, buprenorphine hydrochloride and/or buprenorphine, and a penetration enhancer, wherein the penetration enhancer comprises a combination of a monoglyceride of a fatty acid having 6 to 8 carbon atoms and isopropyl myristate, and the plaster layer contains at least 10 % by weight of a monoglyceride of fatty acid having 6 to 8 carbon atoms and at least 5 % by weight of isopropyl myristate, with the proviso that the content of the whole penetration enhancer ranges from 25 to 50 % by weight. The combined use of the fatty acid monoglyceride and isopropyl myristate as a penetration enhancer synergistically elevates skin penetration of buprenorphine hydrochloride and/or buprenorphine. - 64 -
Fukushima Yasuhiro
Hosokawa Yuko
Ninomiya Kazuhisa
Ochiai Mitsuru
Okumura Mutsuo
Nikken Chemicals Co. Ltd.
Nitto Denko Corporation
Riches Mckenzie & Herbert Llp
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