C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/16 (2006.01) A61K 31/52 (2006.01) A61P 25/28 (2006.01) C07D 473/00 (2006.01) C07D 473/40 (2006.01)
Patent
CA 2374714
The invention concerns novel products of formula (I), wherein: Z represents -CH¿2?-, -SO¿2?-, -CO-, -COO-, -CONH- or -(CH¿2?)¿2?-NR¿3?-; n represents 0 or 1; R¿1? represents hydrogen, aryl, -CH¿2?-aryl, -SO¿2?-aryl, -CO-aryl, heterocyclic, -CH¿2?- heterocyclic, alkyl and -SO¿2?-alkyl; R¿2? represents alkyl, cycloalkyl or heterocycle containing oxygen, sulphur or NR¿3?; Y represents oxygen, sulphur or NR¿3?; D¿1? and D¿2? are either selected among hydrogen, hydroxyl, alkyl, alkoxy and NHR¿5?, or form =O, or =N-OR¿4?; R¿3? represents hydrogen, alkyl or cycloalkyl; R¿4? represents hydrogen, alkyl, cycloalkyl or aryl; R¿5? represents hydrogen, alkyl, cycloalkyl or -COOtbu; R¿6? represents hydrogen, halogen, hydroxyl, alkyl, alkoxy or NHR¿3?; said products being all in isomeric forms and their salts, as medicines.
L'invention concerne les nouveaux produits de formule (I), dans laquelle: Z représente -CH2-, -SO2-, -CO-, -COO-, -CONH- ou -(CH2)2-NR3-, n représente O ou 1, R1 représente hydrogène, aryle, -CH2-aryle, -SO2-aryle, -CO-aryle, hétérocyclique, -CH2-hétérocyclique, alkyle et -SO2-alkyle, R2 représente alkyle, cycloalkyle ou hétérocycle renfermant oxygène, soufre ou NR3, Y représente oxygène, soufre ou NR3, D1 et D2 soit sont choisis parmi hydrogène, hydroxyle, alkyle, alcoxy et NHR5, soit forment =O, ou =N-OR4, R3 représente hydrogène, alkyle ou cycloalkyle, R4 représente hydrogène, alkyle, cycloalkyle ou aryle, R5 représente hydrogène, alkyle, cycloalkyle ou -COOtbu, R6 représente hydrogène, halogène, hydroxyle, alkyle, alcoxy ou NHR3, ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments.
Aventis Pharma S.a.
Robic
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