Method of treating cognitive decline due to sleep...

Details Method of treating cognitive decline due to sleep... Method of treating cognitive decline due to sleep...

A - Human Necessities

61

K

A61K 31/549 (2006.01) A61K 9/20 (2006.01) A61K 31/00 (2006.01) A61K 31/18 (2006.01) A61K 31/381 (2006.01) A61K 31/4015 (2006.01) A61K 31/454 (2006.01) A61K 31/498 (2006.01) A61K 31/5365 (2006.01) A61K 31/5377 (2006.01) A61M 1/00 (2006.01) A61P 25/20 (2006.01)

Patent

CA 2509251

This invention relates to methods of use for AMPA receptor potentiator compounds and pharmaceutical compositions in the prevention and treatment of cognitive impairment as a result of acute or chronic sleep deprivation, including enhancement of receptor functioning at synapses in brain networks responsible for higher order behaviors. A still further aspect of the present invention is the use of an active agent as described above for the preparation of a medicament for the treatment of a disorder as described above.

L'invention concerne des méthodes d'utilisation de composés de potentialisation du récepteur AMPA et des compositions pharmaceutiques dans la prévention et le traitement d'un trouble cognitif dû au manque de sommeil aigu ou chronique. Ces méthodes consistent à améliorer un récepteur fonctionnant au niveau de synapses de réseaux cérébraux responsables de comportements d'ordre supérieur. Selon un autre aspect, l'invention concerne l'utilisation d'un agent actif tel que décrit ci-dessus, pour la préparation d'un médicament destiné au traitement d'un trouble tel que décrit ci-dessus.

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