Prevention and treatment of myocardial failure

Details Prevention and treatment of myocardial failure Prevention and treatment of myocardial failure

A - Human Necessities

61

K

A61K 31/59 (2006.01)

Patent

CA 2155009

Method of increasing the strength of contraction in the mammalian heart muscle by administering to the mammal an effective amount of an activated vitamin D compound, i.e., a 1.alpha.-hydroxylated vitamin D compound which binds with the vitamin D receptor and produces a positive inotropic effect in the heart muscle. The activated vitamin D compound may be given as a means to prevent myocardial failure or to treat myocardial failure.

Procédé permettant d'augmenter la puissance des contractions dans le muscle cardiaque d'un mammifère, et consistant à administrer au mammifère une dose efficace d'un composé de vitamine D activé, en d'autres termes un composé de vitamine D 1alpha-hydroxylé qui se lie avec le récepteur de vitamine D et qui produit un effet inotrope positif dans le muscle cardiaque. Le composé de vitamine D activé peut être administré comme un moyen de prévention ou de traitement de l'insuffisance myocardique.

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