Blood vessel imaging and uses therefor

Details Blood vessel imaging and uses therefor Blood vessel imaging and uses therefor

A - Human Necessities

61

B

A61B 6/00 (2006.01)

Patent

CA 2694166

Methods are disclosed for analyzing representations of one or more structures in the body of a subject (e.g., a human subject or other animal subject) to glean information about the health of the subject or to evaluate the subject's response to a therapy or other condition. Aspects of the invention relate to obtaining structural information from casts (e.g., vascular casts from animal models) and using the information as a reference for evaluating structures in the body of a subject. Methods are disclosed for diagnosing, staging, grading, and monitoring diseases. Methods also are disclosed for targeting treatments, monitoring the effectiveness of therapies, and/or screening or validating therapies based analyzing structures (e.g., vascular structures) in a subject and comparing them to reference structures observed in casts obtained from models (e.g., animal models) of related diseases or conditions.

L'invention porte sur des méthodes d'analyse des représentations d'une ou de plusieurs structures du corps d'un sujet (homme ou animal) pour obtenir des informations sur son état de santé ou évaluer sa réponse à une thérapie ou à d'autres conditions. Certains aspects de l'invention portent sur le recueil d'informations structurelles provenant de clichés (par exemple de clichés vasculaires de modèles animaux) et sur l'utilisation de ces informations comme référence pour évaluer certaines structures du corps d'un sujet. L'invention porte également sur des méthodes de diagnostic, stadification, classement et suivi de maladies. L'invention porte en outre sur le ciblage de traitements, le suivi de l'efficacité de thérapies, et/ou le criblage ou la validation de thérapies se basant sur l'analyse de structures (par exemple vasculaires) de sujets, et leur comparaison avec des structures de référence observées dans des clichés obtenus de modèles (par exemple animaux) de maladies ou états associés.

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