Process for the production of 9-cis retinoic acid

Details Process for the production of 9-cis retinoic acid Process for the production of 9-cis retinoic acid

C - Chemistry, Metallurgy

07

C

C07C 403/20 (2006.01)

Patent

CA 2520018

A new industrially applicable process for the production of 9-(Z)-retinoic acid is described which is characterized by the conversion of an alkali metal salt of 3-methyl-4-oxocrotonic acid with a C15-triphenyl-phosphonium salt. 9- (Z)-retinoic acid is a versatile compound for the treatment of numerous dermatological diseases.

L'invention concerne un nouveau procédé applicable en industrie pour la production d'acide 9-(Z)-rétinoïque, caractérisé en ce qu'il comprend la conversion d'un sel métallique alcali d'acide 3-méthyl-4-oxocrotonique avec un sel de C¿15?-triphényl-phosphonium. L'acide 9-(Z)-rétinoïque est un composé polyvalent dans le traitement de nombreuses maladies dermatologiques.

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