Inactivated respiratory syncytial viral vaccines

Details Inactivated respiratory syncytial viral vaccines Inactivated respiratory syncytial viral vaccines

A - Human Necessities

61

K

A61K 39/155 (2006.01) C12N 7/02 (2006.01) C12N 7/04 (2006.01) C12N 7/06 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2167274

An immunogenic composition capable of producing a respiratory syncytial (RS) virus specific immune response in a host immunized therewith comprises purified, inactivated RS virus which is substantially free from cellular and serum components and which is non--infectious, non-immunopotentiating, immunogenic and protective. The virus is grown on a vaccine quality cell line and harvested virus is purified under non-denaturing conditions to be substantially free from cellular and serum components. The purified RS virus is inactivated using .beta.-propiolactone, a non-ionic detergent, particularly n-octyl- .alpha.-D-glucopyranoside and n-octyl-.beta.-D-glucopyranoside, or ascorbic acid. The immunogenic composition may be formulated as a vaccine for in vivo administration to a human host. The immunogenic composition also may be used in diagnostic applications.

Composition immogène capable de produire une réponse immune spécifique contre le virus syncytial respiratoire (RS) chez un hôte immunisé, comprenant le virus RS inactivé et purifié qui est sensiblement dépourvu de composants cellulaire et sériques et qui est non infectieux, non immunopotentialisateur, immunogène et protecteur. Le virus est cultivé sur une lignée cellulaire du type vaccin et le virus récolté est purifié dans des conditions non dénaturantes pour être sensiblement dépourvu de composants cellulaires et sériques. Le virus RS purifié est inactivé avec de la beta -propiolactone, un détergent non ionique plus spécifiquement du n-octyl- alpha -D-glucopyromoside et du n-octyl- beta -D-glucopyramoside, ou de l'acide ascorbique. La composition immunogène peut être formulée sous forme d'un vaccin qui s'administre in vivo à un hôte humain. La composition immonogène peut également être utilisée dans des applications de diagnostic.

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