C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/25 (2006.01) B01J 19/00 (2006.01) B01L 3/00 (2006.01) C12M 1/34 (2006.01) C12M 1/40 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 35/08 (2006.01)
Patent
CA 2258489
The present invention provides microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems. The device includes a series of channels (110, 112), and optional reagent channel (114), fabricated into the surface of the substrate. At least one of these channels will typically have very small cross-sectional dimensions, e.g. in the range of from about 0.1 hem to about 500 µm. The device also includes reservoirs (104, 106 and 108), disposed and fluidly connected at the ends of the channels (110 and 114). As shown, sample channel (112) is used to introduce the plurality of different test compounds into the device. As such, this channel will generally be fluidly connected to a source of large numbers of separate test compounds that will be individually introduced into the sample channel (112) and subsequently into channel (110).
L'invention porte sur des dispositifs microscopiques de transfert de fluides et les procédés associés servant à effectuer des dosages de criblage à fort rendement portant en particulier sur grand nombre de composés différents pour en étudier les effets sur différents systèmes chimiques et de préférence biochimiques. Un tel dispositif comporte une série de canaux (110, 112) et facultativement un canal (114) destiné à un réactif tracé à la surface du substrat. L'un au moins de ces canaux présente normalement une section droite de très faibles dimensions par exemple comprise entre environ 0,1 mu m et environ 500 mu m; il comporte également des réservoirs (104, 106, 108) disposés aux extrémités des canaux (110 et 114) et communiquant avec eux. On remarquera que le canal (112) de transfert d'échantillons sert à l'introduction des différents composés de test dans le dispositif. A ce titre, ledit canal est normalement relié à une source d'un grand nombre de composés à tester qui sont introduits séparément dans le canal (112) puis passent dans le canal (110).
Bousse Luc J.
Kopf-Sill Ann R.
Parce John Wallace
Caliper Technologies Corporation
Fetherstonhaugh & Co.
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