Encapsulation method

Details Encapsulation method Encapsulation method

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 47/34 (2006.01) B01J 13/18 (2006.01)

Patent

CA 2306824

A novel method of encapsulating an active substance in a biodegradable polymer, which comprises: a) dissolving said biodegradable polymer in an organic solvent therefor; b1) dispersing said active substance in the organic solution obtained in step a), to provide a dispersion with the active substance as the inner phase thereof; or alternatively b2) emulsifying said active substance, dissolved in water or other aqueous solvent therefor, in the organic solution obtained in step a), to provide an emulsion with the active substance as the inner aqueous phase thereof; and c) subjecting the dispersion obtained in step b1), or alternatively the emulsion obtained in step b2), to an encapsulation operation with an aqueous polyethylene glycol solution as a continous phase, to provide micro- or nanoparticles having the active substance encapsulated therein. Sustained release particles obtainable therebs.

L'invention concerne un nouveau procédé permettant d'encapsuler une substance active dans un polymère biodégradable. Ce procédé consiste a) à dissoudre le polymère biodégradable dans un solvant organique; b1) à disperser la substance active dans la solution organique obtenue en a), afin de produire une dispersion avec la substance active comme phase interne ou, en variante, b2) à émulsionner la substance active, dissoute dans de l'eau ou un autre solvant aqueux, dans la solution organique obtenue en a), afin de produire une émulsion avec la substance active comme phase aqueuse interne; et c) à soumettre la dispersion obtenue en b1) ou, en variante, l'émulsion obtenue en b2) à une opération d'encapsulage par une solution aqueuse de polyéthylènglycol comme phase continue, afin de produire des microparticules ou nanoparticules encapsulant la substance active. L'invention concerne également les particules à libération continue ainsi obtenues.

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