Process for preparing chiral tetracyclic dopaminergic compounds

Details Process for preparing chiral tetracyclic dopaminergic compounds Process for preparing chiral tetracyclic dopaminergic compounds

C - Chemistry, Metallurgy

07

D

C07D 221/18 (2006.01) A61K 31/47 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2195676

A process for preparing a chiral tetracyclic compound of formula (1), wherein R is hydrogen or a C1-C6-alkyl group and Z is oxygen, sulfur or -CH=CH-, the compounds having uses as dopamine agonists. The process involves reacting a chiral starting material and subsequent chiral intermediates in a series of chirality-preserving synthetic reactions.

Procédé de préparation d'un composé tétracyclique chiral de la formule (1), dans laquelle R représente hydrogène ou un groupe alkyle C1-C6 et Z représente oxygène, soufre ou -CH=CH-, ces composés agissant comme agonistes de la dopamine. Ce procédé consiste à faire réagir une matière de départ chirale et des intermédiaires chiraux ultérieurement formés en une série de réactions de synthèse maintenant la chiralité.

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