Process for the preparation of pyrazolidin-3-ones

Details Process for the preparation of pyrazolidin-3-ones Process for the preparation of pyrazolidin-3-ones

C - Chemistry, Metallurgy

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D

260/315.5

C07D 231/08 (2006.01) G03C 5/30 (2006.01)

Patent

CA 1165323

Process for the preparation of pyrazolidin-3-ones Abstract In a one-vessel reaction or in two separate stages, pyrazolidin-3-ones are prepared by reacting a .beta.-hydroxy- propionic acid of the formula Image in which R2 is alkyl or hydroxyalkyl and R3 is hydroxyalkyl, with a phenylhydrazine of the formula Image in which R4 is hydrogen, alkyl, alkoxy, hydroxyl or halogen, to give a .beta.-hydroxypropionic acid hydrazide, and subse- quently cyclising the hydrazide. An acid catalyst is present during the cyclisation of the hydrazide and, optionally, even during its formation from the acid component and the hydrazine component. The process leads to high yields of pyrazolidin-3- ones after a short reaction time.

391818

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